Zhong Yuan Biotech found Nervonic acid may have neuroprotective effect on high-altitude HIE patients.

• Date：2023-10-02

• By：Zhong Yuan Biotech

Recently, a team of researchers led by Dr. Xianyang Chen from Beijing Bao Feng, a prominent provider of comprehensive brain health solutions in China, collaborated with Professor Li Jiujun, Vice Dean of the Children's Hospital of China Medical University. Their groundbreaking study was published in a prestigious international journal and, validated the neuroprotective effects of the Nervonic acid substances found in Bao Feng's proprietary Acer truncatum seed oil on HIE model mice. Simultaneously, the research harnessed transcriptomics in conjunction with targeted and untargeted metabolomics techniques to unveil the molecular mechanisms of Nervonic acids' in vivo action, specifically their role in regulating brain lipid metabolism and phospholipid synthesis, mitigating lipid peroxidation damage.

Screenshot from the Journal "Communications Biology"

It has been reported that a collaborative research team, in a groundbreaking study, recently published a paper in the journal "Communications Biology" with the title "Multi-omics reveal neuroprotection of Acer truncatum Bunge Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude." This publication, affiliated with the Nature Publishing Group, represents a significant milestone in the field, offering novel insights into a dedicated area of research. The release of this research paper underscores the global recognition and attention garnered by Beijing Bao Feng's investigation into the Nervonic acid extract of Acer truncatum Bunge Seed. Particularly noteworthy is the elucidation and substantiation of the mechanisms of Nervonic acids' actions in this study, which lays a robust theoretical foundation for future Nervonic acid drug development.

The mechanism diagram of the intervention of ASO on neuroprotection

The research findings presented in this study are the result of a collaborative effort between the research team at Beijing Bao Feng and the research team at the Children's Hospital of China Medical University. Notably, this marks the second substantial publication in high-impact factor journals within a span of just two months. In July 2023, these two teams jointly published a paper in the prestigious scientific journal "Food & Function," classified within the top tier of international journals. The paper was titled " Lipidomics reveal the cognitive improvement effects of Acer truncatum Bunge seed oil on hypoxic–ischemic encephalopathy rats." Subsequently, in September 2023, the same research teams published the paper in "Communications Biology."

 Screenshot from the Journal "Food Function"

These research outcomes conclusively demonstrate the potential of Bao Feng's proprietary Nervonic acid extract derived from the Acer truncatum Bunge Seed, marketed as "Mu Zhi Yuan Nervonic acid Oil" with the patent certificate ZL202010816389.2. Regardless of whether it's in plain or high-altitude regions, this exclusive product has been proven to have a beneficial impact on cognitive and behavioral impairments resulting from hypoxia and ischemia.

Bao Feng Bio-technology (Beijing) Ltd. is a cutting-edge biotechnology company specializing in brain science and technology, brain health screening, and the research and production of brain health products. Established in 2012, the company is headquartered in Beijing and has set up research centers, production bases, and raw material bases in Beijing, Anhui, Jilin, and Zhuhai. Bao Feng focuses on the development of brain health products, including functional food products for neurological disorders, new drug research, and the development of medical devices such as brain disease diagnostic test kits. We have obtained 19 national invention patents. The brain health screening and intervention products have been widely implemented.

(Picture shows Bao Feng R & D team and patent wall display)

(The picture shows the unveiling ceremony of the cooperation project between Bao Feng and Zhongguancun Key Laboratory of Genetic Metabolism)

As a leader in the field of brain health products, Baofeng Biological Technology has strategically positioned itself in the clinical domain. They have established patent layouts and possess two major independent technology research and development platforms: the "Genetic Metabolism + Clinical Mass Spectrometry" platform and the "Medical Big Data Mining + Machine Learning" platform. The company conducts various clinical research and research projects at the provincial and ministerial levels. They have also established a "National Key Laboratory of Genetic Metabolism Research." Collaboration with hospitals that involves multi-level clinical research and technology services, including clinical sample data analysis, disease molecular subtyping, pharmacology, safety assessment, and biomarker selection, gives comprehensive research and technical foundation to company.

Beijing Bao Feng places a strong emphasis on the integration of production, academia, and research. They have developed a range of brain health products catering to different age groups, including the elderly, middle-aged adults, and teenagers, based on high-purity active Nervonic acid. This product line includes gel candy, oral liquids, and dietary formula oil. These products have gained favor in the market.

(Baofeng Biotech full range of products display picture)