Original Research Achievement: Zhong Yuan Nervonic acid provide new approach for HIE Treatment

• Date：2023-07-25

• By：Zhong Yuan Biotech

Recently, Beijing Bao Feng, as a leading domestic provider of comprehensive brain health solutions, has made a groundbreaking discovery using lipidomics research. They have revealed the outstanding performance of Nervonic acid substances in Acer Truncatum Seed Oil in enhancing cognitive function and brain injury improvement. Additionally, they have found that Acer Truncatum Seed Oil can have potential applications as a nutritional supplement in patients with HIE (hypoxic-ischemic encephalopathy). This research achievement was published in the top global journal in the field of food science, "Food & Function," with the study conducted on the exclusive patented product of Beijing Bao Feng , the "Muzhiyuan Nervonic acid Oil" (Product Patent Certificate: ZL202010816389.2).

Screenshot of journal electronic edition

The original link: https://pubmed.ncbi.nlm.nih.gov/37395364/

The achievement has garnered extensive attention from research, medical, and investment institutions, not only due to the pioneering research on Nervonic acid as nutritional supplements but also because of its groundbreaking impact on HIE treatment. HIE, being a rare disease, has long been the subject of research interest, but the difficulty of treatment and limited therapeutic options have led to a lack of effective intervention methods for an extended period. The research findings from Bao Feng provide fresh insights and innovative approaches to tackle this global challenge, holding significant implications for improving the quality of life and recovery of HIE patients. It is foreseeable that the promotion and application of this groundbreaking research will bring revolutionary changes to the field of brain and neurological disease treatment, exerting profound effects on the global brain health industry's development.

Hypoxic-ischemic encephalopathy (HIE) is one of the primary causes of acute neonatal death and chronic neurological damage, and severe cases of HIE can result in secondary sequelae such as cognitive impairment and cerebral palsy. However, currently, effective intervention measures are still lacking. In this study, the research and development team at Beijing Bao Feng successfully mitigated brain damage in HIE rats and significantly improved their cognitive abilities by administering Acer Truncatum Seed Oil (ASO) for 30 consecutive days. The results observed through lipidomics analysis showed a decrease in unsaturated fatty acids and an increase in lyso-phospholipids in the brains of HIE rats. However, after 30 days of ASO treatment, there was an increase in phospholipids, phosphatidylcholines, and unsaturated fatty acids in both the serum and brain tissue, while lyso-phospholipids and oxidized glycerophospholipids decreased. Enrichment analysis indicated that ASO intake mainly affected sphingolipid metabolism, fat digestion and absorption, glycerolipid metabolism, and glycerophospholipid metabolism pathways in the serum and brain. Cluster analysis, correlation analysis, and confirmatory factor analysis further confirmed that the cognitive improvement after ASO treatment could be attributed to the increase in essential phospholipids and ω3/6/9 fatty acids in the brains of HIE rats and the decrease in oxidized glycerophospholipids. These research findings suggest that ASO holds the potential to become an effective food supplement for infants with ischemic-hypoxic conditions.

The results showed that Acer Truncatum Seed oil (ASO) could reduce brain damage and improve cognitive ability in rats with HIE

"Food & Function" is one of the world's top professional journals in the field of food science, ranking in the top 5 globally. Published by the Royal Society of Chemistry in the United Kingdom, the journal has an SCI impact factor of 6.317 (2022-2023). It primarily focuses on publishing the best original research papers, reviews, and new theoretical and technological research papers related to food research and health functionality. As a highly reputable platform, it provides the most professional and authoritative content dissemination for leading physicists, chemists, biologists, and nutritionists worldwide. The groundbreaking research achievement published by Beijing Bao Feng in this journal not only establishes a theoretical foundation for the potential application of Bao Feng seed extract as a neuro-nutritional supplement for neonatal hypoxic-ischemic encephalopathy but also provides a viable path to tackle the global challenge of brain and neurological diseases. This research expands the theoretical and applied research on Nervonic acid in the medical field, holding significant clinical and societal value.

Bao Feng Technology (Beijing) Ltd. is an advanced biotechnology company specializing in brain science technology, brain health screening, and the research and production of brain health products. Established in 2012 and headquartered in Beijing, the company has set up research and development centers, production bases, and raw material bases in Beijing, Anhui, Jilin, and Zhuhai. It focuses on the research and development of brain health products, including functional foods targeting neurological diseases, the development of new drugs, and the creation of third-class medical devices such as brain disease detection test kits. The company has obtained 19 national invention patents. Its brain health screening and intervention products have been extensively implemented.

Beijing Bao Feng places great emphasis on the integration of industry, academia, and research. Building upon high-purity active Nervonic acid, they have developed a range of brain health products tailored for different age groups, including the middle-aged and elderly, young adults, and adolescents. These products, such as essential oils, gummy candies, oral solutions, and edible oil formulations, have gained popularity and favor in the market.

Images show the Bao Feng Biotech research and development team along with a display of patent certificates.

Image shows the unveiling ceremony of the collaborative project between Bao Feng Biotech Key Laboratory of Genetic Metabolism, Zhongguancun.

Beijing Bao Feng Biotechnology emphasizes the integration of industry, academia, and research. Based on high-purity active Nervonic acid, they have developed a range of brain health products tailored for middle-aged and elderly individuals, young adults, and teenagers. This product line includes essential oils, gel candies, oral liquids, and edible formula oils, which have gained popularity in the market.

Images showcase the full range of Bao Feng Biotech products